Bisphosphonates의 화학적 구조 및 작용 기전
Bisphosphonates - their Chemical Structures and Action Mechanisms
이현우,
소속 상세정보
이현우 ( Lee Hyeon-Woo ) - 경희대학교 치의학전문대학원 치과약리학교실
KMID : 1033920090060010001
Abstract
Bisphosphonates (BPs), pyrophosphate analogues, have been widely prescribed as agents against osteoclast-induced bone loss, Paget’s disease, bone malignancies, multiple myeloma, and hyercalcemia of malignancy. Selective action on bone is based on physical association of BPs moiety to the bone mineral. Recently, clinical uses of N-BPs (nitrogen-containing BPs) have been reported to be linked with several pathogenic conditions such as osteonecrosis of the low jaw. This may trigger to need the thorough examination of current uses of BPs therapy. Here, we review current understanding of the molecular action mechanisms of BPs and their chemical structures.
키워드
Bisophosphonates; Osteoclasts; Action mechanisms
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